V.Hardt, R. Mennicken, A. K. Motovilov Factorization Theorem for the Transfer Function of a $2\times2$ Operator Matrix with Unbounded Couplings (168K, PostScript) ABSTRACT. We consider the analytic continuation of the transfer function associated with a $2\times2$ operator matrix having unbounded couplings into unphysical sheets of its Riemann surface. We construct a family of non-selfadjoint operators which factorize the transfer function and reproduce certain parts of its spectrum including the nonreal (resonance) spectrum situated in the unphysical sheets neighboring the physical sheet.